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Mitohondriji u dendritskim stanicama ključ za jaču imunoterapiju

(1w ago)
Memphis, United States
genengnews.com
Mitohondriji u dendritskim stanicama ključ za jaču imunoterapiju

Mitohondriji u dendritskim stanicama ključ za jaču imunoterapiju📷 © Tech&Space

  • ★Tumori onesposobljavaju dendritske stanice preko metaboličkog mehanizma
  • ★Poboljšana mitohondrijska funkcija pojačava protuumorni imunitet
  • ★Preklinički rezultati na miševima otvaraju nova istraživačka pitanja

Dendritske stanice, ključni „vratari“ imunološkog sustava, postaju meta tumora koji ih onesposobljavaju putem metaboličkog mehanizma. Prema studiji objavljenoj na GEN - Genetic Engineering and Biotechnology News, istraživači sa St.

Jude Children’s Research Hospital utvrdili su da tumori smanjuju funkciju ovih stanica tako što narušavaju njihovu mitohondrijsku aktivnost. Reprogramiranje metabolizma mitohondrija u dendritskim stanicama rezultira smanjenom sposobnošću aktiviranja imunološkog odgovora na rak.

Rezultati pokazuju da obnova mitohondrijske funkcije ne samo da pojačava protuumorni imunitet, nego i poboljšava učinkovitost postojećih imunoterapija.

Novo otkriće pokazuje kako obnova mitohondrija može poboljšati učinkovitost terapija — ali samo u istraživačkom stadiju

Novo otkriće pokazuje kako obnova mitohondrija može poboljšati učinkovitost terapija — ali samo u istraživačkom stadiju📷 © Tech&Space

Novo otkriće pokazuje kako obnova mitohondrija može poboljšati učinkovitost terapija — ali samo u istraživačkom stadiju

U prekliničkim modelima na miševima, dendritske stanice s visokom mitohondrijskom aktivnošću, kada su ubrizgane u tumore, obnovile su imunogenu aktivnost i poboljšale kontrolu rasta tumora. Ovo je posebno zanimljivo u kombinaciji s inhibitorima imunoloških kontrolnih točaka, gdje je uočeno „najizraženije terapeutsko djelovanje“, kako ističu autori.

Međutim, važno je naglasiti da se radi o prekliničkim nalazima—rezultati na miševima ne garantiraju isti učinak kod ljudi. Studija, iako visoke metodološke razine, još uvijek zahtijeva potvrdu u kliničkim ispitivanjima na ljudima, što znači da je do potencijalne primjene u praksi još daleko.

Metodologija istraživanja uključivala je analizu kako tumori utječu na metabolizam dendritskih stanica, s fokusom na mitohondrije kao centralnu točku. „Tumori reprogramiraju mitohondrijski metabolizam dendritskih stanica, smanjujući njihovu sposobnost aktiviranja imunološkog sustava protiv raka“, objašnjava jedan od autora.

MitochondriaImmunotherapyDendritic Cells

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