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Nova strategija u borbi protiv leukemije

(1w ago)
Global
genengnews.com
Nova strategija u borbi protiv leukemije

Nova strategija u borbi protiv leukemije📷 © Tech&Space

  • ★CRISPR screening
  • ★Epigenetička ciljanja
  • ★Tumor supresor

Istraživači su koristili CRISPR screening i epigenetičku ciljanju kako bi identificirali enzime koji mogu biti inhibirani za reaktivaciju tumorskog supresora u modelima akutne mijeloidne leukemije. Ova strategija mogla bi ponuditi manje toksičnu alternativu kemoterapiji za AML.

Prema dostupnim informacijama, istraživači su također otkrili da inhibicija KDM4 enzima u AML modelima miševa može restaurirati aktivnost tumorskog supresora ZBTB7A i smanjiti leukemijsko opterećenje. Istraživači su koristili alat zvani FISHnCRISP kako bi kartirali aktivnost gena u AML stanici.

Ova studija je također pokazala da AML stanice proizvode duži regulatorni rep ZBTB7A koji privlači ZFP36L2, što smanjuje aktivnost gena. KDM4 enzimi također su utvrđeni kao važni za silenciranje ZBTB7A ekspresije modificiranjem pakovanja DNK. GEN - Genetic Engineering and Biotechnology News objavio je detalje o ovoj studiji. The Jackson Laboratory je također bio uključen u istraživanje.

Što studija stvarno pokazuje o novoj strategiji

Što studija stvarno pokazuje o novoj strategiji📷 © Tech&Space

Što studija stvarno pokazuje o novoj strategiji

Ova studija ima veliki potencijal za razvoj nove terapije za AML. Međutim, još uvijek je potrebno provesti klinička ispitivanja kako bi se potvrdila sigurnost i učinkovitost ove strategije.

Prema Ericu Wangu, PhD, sa JAX-a, „Ako možemo identificirati koji geni su bili silencirani i razumjeti kako ih vratiti natrag, to bi moglo otvoriti potpuno nove terapijske mogućnosti“. National Institutes of Health podržava istraživanja u ovom području. American Cancer Society također pruža informacije i resurse za pacijente s AML-om. Kako bi se dalje istražilo ovo otkriće, potrebno je nastaviti finansirati istraživanja i klinička ispitivanja.

Razina dokaza: istraživački stadij. Ova studija je još uvijek u ranim fazama, i potrebno je više istraživanja kako bi se potvrdila njena učinkovitost i sigurnost.

Razvoj ove nove strategije je rezultat suradnje između istraživača i znanstvenika. Ova studija predstavlja veliki doprinos u borbi protiv leukemije i može pružiti nadu pacijentima s AML-om. Potrebno je nastaviti istraživati i razvijati nove terapije kako bi se poboljšala kvaliteta života pacijenata s AML-om.

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